科研情況 |
專業:微生物與免疫學 研究方向: 1.沙門氏菌分離、鑒定及耐藥性研究 探究沙門氏菌分離鑒定方法、沙門氏菌耐藥表型及其與耐藥基因的關系,闡明沙門氏菌耐藥機制. 2.肝臟腫瘤免疫學 探究天然模式識別受體在肝癌轉移中的作用及分子機制,為肝癌治療提供理論依據. 主持項目: (1)國家自然科學基金青年科學基金項目—NLRP3炎癥小體通過促進NK細胞功能抑制肝癌轉移及機制研究(2019.1-2021.12) 代表性論文: 1.Xin Yu, Peixiang Lan, Xuben Hou, Qiuju Han, Nan Lu, Tao Li, Chenwei Jiao, Jian Zhang, Cai Zhang*, Zhigang Tian*. HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1bproduction via suppressing NF-kB pathway and ROS production, Journal of Hepatology, 2017; 66(4):693-702. 2.Xin Yu#, Hongru Zhang#, Linyan Yu, Meifang Liu, Qiuju Han, Jian Zhang, Zhigang Tian, Cai Zhang*. Intestinal lamina propria CD4+T cells promote bactericidal activity of macrophages via galectin-9 and Tim-3 interaction duringSalmonella typhimuriuminfection. Infection and Immunity, 2018;86(8). 3.于馨,張彩*.炎癥小體信號通路的負調控.生物化學與生物物理進展, 2014;41(1):87-95. 4. Zhixia Zhou,Xin Yu, Jian Zhang, Zhigang Tian, Cai Zhang*.TLR7/8 agonists promote NK-DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma. Cancer Letters, 2015; 369(2):298-306. 5. Qie Guo, Peixiang Lan,Xin Yu, Qiuju Han, Jian Zhang, Zhigang Tian, Cai Zhang*. Immunotherapy for hepatoma using a dual-function vector with both immunostimulatory and Pim-3-silencing effects. Molecular Cancer Therapeutics, 2014; 13(6):1503-1513. *通訊作者,#共第一作者. |